OLIG2 Monoclonal Antibody - BT-MCA4423

OLIG2 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4423-50, BT-MCA4423-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. Tissue specificity: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.

Research Areas: Epigenetics and nuclear signaling, Neuroscience, Stem cells

Target Protein: OLIG2

Applications: IHC, ICC

Reactivity: Human

Clonality: Monoclonal

Clone ID: 1G11

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: OLIG2

Immunogen: Purified recombinant fragment of human OLIG2 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 32kDa

UniProt Accession: Q13516

Synonyms: BHLHB1, OLIGO2, RACK17, PRKCBP2, bHLHe19, OLIG2

GeneID: 10215

Research Use Only