Product Description

OLR1 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES11225-50, ES11225-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010],

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human protein. at AA range: 60-140

Isotype: IgG

Target: OLR1

Specificity: OLR1 Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Expressed at high level in endothelial cells and vascular-rich organs such as placenta, lung, liver and brain, aortic intima, bone marrow, spinal cord and substantia nigra, Also expressed at the surface of dendritic cells, Widely expressed at intermediate and low level,

Observed Band (KD): 30kD

Fields: PPAR signaling pathway, Phagosome, Lipid and atherosclerosis

Function: Disease: Defects in OLR1 may be a cause of susceptibility to myocardial infarction [MIM: 608557]
Disease: Defects in OLR1 may be associated with susceptibility to Alzheimer disease (AD) [MIM: 104300]. Involvement in AD is however unclear: according to some authors (PubMed: 12354387, PubMed: 12810610 and PubMed: 15976314), variations in OLR1 modify the risk of AD, while according to other (PubMed: 15000751 and PubMed: 15060104) they do not
Domain: The C-type lectin domain mediates the recognition and binding of oxLDL
Domain: The cytoplasmic region is required for subcellular sorting on the cell surface
Function: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammat

Subcellular Location: Cell membrane, Lipid-anchor Cell membrane, Single-pass type II membrane protein Membrane raft Secreted A secreted form also exists Localization to membrane rafts requires palmitoylation

Storage and Stability: -20°C/1 year

Gene Name: OLR1 CLEC8A LOX1

Protein Name: Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) (C-type lectin domain family 8 member A) (Lectin-like oxidized LDL receptor 1) (LOX-1) (Lectin-like oxLDL receptor 1) (hLOX-1) (Lectin-t

Mouse SwissProt Number: Q9EQ09

Rat SwissProt Number: O70156

Research Use Only