Product Description

OPT Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES10911-50, ES10911-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Opticin belongs to class III of the small leucine-rich repeat protein (SLRP) family. Members of this family are typically associated with the extracellular matrix. Opticin is present in significant quantities in the vitreous of the eye and also localizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver. Opticin may noncovalently bind collagen fibrils and regulate fibril morphology, spacing, and organization. The opticin gene is mapped to a region of chromosome 1 that is associated with the inherited eye diseases age-related macular degeneration (AMD) and posterior column ataxia with retinosa pigmentosa (AXPC1). [provided by RefSeq, Jul 2008],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from part region of human protein

Isotype: IgG

Target: OPT

Specificity: OPT Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Expressed in cartilage and synovial membranes (at protein level) (PubMed:18164633, PubMed:23845380), Expressed in the retina, iris, ligament, skin and fetal liver (at protein level) (PubMed:12019215, PubMed:25136834), Expressed in the retinal pigment epithelium (at protein level) (PubMed:25136834), Expressed in synovial fibroblasts and subchondral bone osteoblasts (PubMed:18164633),

Observed Band (KD): 36kD

Function: Function: Binds collagen fibrils
PTM: O-glycosylated
Similarity: Belongs to the small leucine-rich proteoglycan (SLRP) family. Class III subfamily
Similarity: Contains 7 LRR (leucine-rich) repeats
Tissue Specificity: Retina, iris, ligament, skin and fetal liver

Subcellular Location: Secreted, extracellular space, extracellular matrix

Storage and Stability: -20°C/1 year

Gene Name: OPTC OPT

Protein Name: Opticin (Oculoglycan)

Mouse SwissProt Number: Q920A0

Research Use Only