Product Description

OSBP1 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES14364-50, ES14364-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Oxysterol binding protein is an intracellular protein that is believed to transport sterols from lysosomes to the nucleus where the sterol down-regulates the genes for the LDL receptor, HMG-CoA reductase, and HMG synthetase [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human OSBP1 AA range: 284-334

Isotype: IgG

Target: OSBP1

Specificity: This antibody detects endogenous levels of OSBP1 at Human/Mouse

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Widely expressed,

Molecular Weight (Da): 89kD

Function: Domain: The PH and Ala/Gly-rich domains control cholesterol binding without affecting 25-hydroxycholesterol binding
Domain: The second coiled-coil domain is required for interaction with the tyrosine phosphatase
Function: Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability
Similarity: Belongs to the OSBP family
Similarity: Contains 1 PH domain
Subcellular Location: When bound to oxysterols, translocates to the periphery of Golgi membranes
Subunit: Homodimer or homotrimer
Tissue Specificity: Widely expressed

Subcellular Location: Cytoplasm, cytosol Cytoplasm, perinuclear region Golgi apparatus membrane, Peripheral membrane protein Endoplasmic reticulum membrane, Peripheral membrane protein Golgi apparatus, trans-Golgi network Predominantly cytosolic

Storage and Stability: -20°C/1 year

Gene Name: OSBP OSBP1

Protein Name: OSBP1

Mouse Gene ID: 76303

Mouse SwissProt Number: Q3B7Z2

Research Use Only