Product Description

OVOL2 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES10377-50, ES10377-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the evolutionarily conserved ovo-like protein family. Mammalian members of this family contain a single zinc finger domain composed of a tetrad of C2H2 zinc fingers with variable N- and C-terminal extensions that contain intrinsically disordered domains. Members of this family are involved in epithelial development and differentiation. Knockout of this gene in mouse results in early embryonic lethality with phenotypes that include neurectoderm expansion, impaired vascularization, and heart anomalies. In humans, allelic variants of this gene have been associated with posterior polymorphous corneal dystrophy. [provided by RefSeq, Apr 2016],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human protein. at AA range: 90-170

Isotype: IgG

Target: OVOL2

Specificity: OVOL2 Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Expressed in testis, ovary, heart and skeletal muscle (PubMed:12213202), Expressed in the cornea, but absent from the corneal endothelium (PubMed:26749309),

Observed Band (KD): 30kD

Function: Function: DNA-binding protein that binds to the 5'-G[GCT]GGGGG-3' core sequence. Probably acts as a transcription regulator
Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
Similarity: Contains 4 C2H2-type zinc fingers

Subcellular Location: Nucleus

Storage and Stability: -20°C/1 year

Gene Name: OVOL2 ZNF339

Protein Name: Transcription factor Ovo-like 2 (hOvo2) (Zinc finger protein 339)

Mouse SwissProt Number: Q8CIV7

Research Use Only