Product Description

p-MSN, RDX, EZR (T558) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65022-50, BS65022-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The ezrin, radixin, and moesin (ERM) proteins function as linkers between the plasma membrane and the actin cytoskeleton and are involved in cell adhesion, membrane ruffling, and microvilli formation. ERM proteins undergo intra or intermolecμlar interaction between their amino- and carboxy-terminal domains, existing as inactive cytosolic monomers or dimers. Phosphorylation at a carboxy-terminal threonine residue (Thr567 of ezrin, Thr564 of radixin, Thr558 of moesin) disrupts the amino- and carboxy-terminal association and may play a key role in regμlating ERM protein conformation and function. Phosphorylation at Thr567 of ezrin is required for cytoskeletal rearrangements and oncogene-induced transformation. Ezrin is also phosphorylated at tyrosine residues upon growth factor stimμlation. Phosphorylation of Tyr353 of ezrin transmits a survival signal during epithelial differentiation.

Category: Primary Antibody

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB

Alternate Names: Moesin, Membrane-organizing extension spike protein, MSN, Radixin, RDX, Ezrin, Cytovillin, Villin-2, p81, EZR

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to Human MSN, RDX, EZR(phospho-T558).

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: MSN, RDX, EZR(phospho-T558) polyclonal antibody detects endogenous levels of MSN, RDX, EZR(phospho-T558) protein.

Molecular Weight: ~ 75, 80 kDa

Pathway: Contribution of ECM and Cytoskeletal Factors to EMT, Contribution of ECM and Cytoskeletal Factors to EMT,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P26038, P35241, P15311

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Research Use Only