P16 Monoclonal Antibody - BT-MCA4176

P16 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4176-50, BT-MCA4176-100

Citations, Manuals and MSDS Available upon request.

Background: The progression of cells through the cell cycle is regulated by a family of protein kinases known as cyclin-dependent kinases (Cdks). The sequential activation of individual members of this family and their consequent phosphorylation of critical substrates promotes orderly progression through the cell cycle. The cyclins function as differentially expressed positive regulators of Cdks. Negative regulators of the cycle include the p53-inducible 21 kDa WAF1/Cip1 protein designated p21, Kip1 p27 and p16. The complexes formed by Cdk4 and the D-type cyclins have been strongly implicated in the control of cell proliferation during the G1 phase. It has recently been shown that p16 binds to Cdk4 and inhibits the catalytic activity of the Cdk4/cyclin D complex. Moreover, the gene encoding p16 exhibits a high frequency of homozygous deletions and point mutations in established human tumor cell lines.

Research Areas: Others

Target Protein: P16

Applications: IHC

Reactivity: Human, Rat

Clonality: Monoclonal

Clone ID: 2D9A12

Host: Mouse

Isotype: Mouse IgG2b

Full Product Name: P16

Immunogen: Purified recombinant fragment of P16 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

UniProt Accession: P42771

Synonyms: P16

GeneID: 1029

Research Use Only