p300 Monoclonal Antibody - BT-MCA0969

p300 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA0969-50, BT-MCA0969-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.

Research Areas: Epigenetics and nuclear signaling; Cancer; Stem cells; Metabolism

Target Protein: EP300

Applications: WB, ELISA

Reactivity: Human

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Histone acetyltransferase p300

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q09472; Mouse: B2RWS6

Synonyms: EP300; P300; Histone acetyltransferase p300; p300 HAT; E1A-associated protein p300

GeneID: Human: 2033

Research Use Only