Product Description

P3C2B Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA33948-50, RA33948-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta (PIK3C2B) Homo sapiens The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008],

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Molecular Weight: 179

Protein Molecular Weight (kDa): 179

Storage: -20°C/1 year

Human Gene ID: 5287

Human SwissProt Number: O00750

Condition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Research Use Only