p53 Monoclonal Antibody - BT-MCA0978

p53 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA0978-50, BT-MCA0978-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons

Research Areas: Epigenetics and nuclear signaling; Cell biology; Cancer

Target Protein: TP53

Applications: WB

Reactivity: Human,Mouse,Rat,Dog

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Cellular tumor antigen p53

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P04637; Mouse: P02340; Rat: P10361

Synonyms: TP53; P53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53

GeneID: Human: 7157; Mouse: 22059; Rat: 24842

Research Use Only