Product Description

p53 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66800-50, MB66800-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: p53, a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor, upregμlates growth arrest and apoptosisrelated genes in response to stress signals, thereby influencing programmed cell death, cell differentiation, and cell cycle control mechanisms. p53 localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regμlator, MDM2. MDM2 is an E3 ubiquitin ligase that is upregμlated in the presence of active p53, where it poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active DNA-binding conformations and is differentially activated through posttranslational modifications, including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD) of p53, amino acids 110-286, can compromise energetically-favorable association with cis elements and are implicated in several human cancers.

Category: Primary Antibody

Reactivity: Human, Monkey

Host: Mouse

Applications: WB

Alternate Names: P53, Cellμlar tumor antigen p53, Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human p53. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000), IHC (1/50 - 1/200)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of p53 protein.

Molecular Weight: ~ 55 kDa

Pathway: AMPK Signaling Pathway, Regμlation of Apoptosis, ErbB HER Signaling, Cell Cycle Control G1 S Checkpoin, Cell Cycle G2 M DNA Damage Signaling Pathway, MTOR signalingNecrotic Cell DeathNeuronal and Glial Cell Marker AtlasNF-kB SignalingNotch SignalingNuclear Receptor SignalingPhosphoinosotode SignalingPhospholipase SignalingPI3K AKT signalingProtein Kinase C SignalingRegμlation of Actin DynamicsRegμlation of ApoptosisRegμlation of Microtubμle DynamicsSAPK JNK Signaling CascadesSignaling Pathways Activating p38 MAP KinaseSTING SignalingT cell receptor signalingTGFβ Smad signalingToll-like Receptor signalingTranslational Contral elF4 and p70 S6 KinaseTranslational Contral Regμlation of elF2Tumor AngiogenesisTumor-Infiltrating Immune Cell Marker GuideUbiquitin ProteasomeVesicle Trafficking presynaptic signalingWarburg EffectWntβ catenin signaling, PI3K AKT signaling, SAPK JNK Signaling Cascades, Warburg Effect

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P04637

Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only