PA28 Gamma Monoclonal Antibody - BT-MCA0983

PA28 Gamma Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA0983-50, BT-MCA0983-100

Citations, Manuals and MSDS Available upon request.

Background: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits| 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) o

Research Areas: Cell biology; Cancer; Immunology

Target Protein: PSME3

Applications: WB, IF, ICC

Reactivity: Human,Mouse,Dog,Pig

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Proteasome activator complex subunit 3

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P61289; Mouse: P61290

Synonyms: PSME3; Proteasome activator complex subunit 3; 11S regulator complex subunit gamma; REG-gamma; Activator of multicatalytic protease subunit 3; Ki nuclear autoantigen; Proteasome activator 28 subunit gamma; PA28g; PA28gamma

GeneID: Human: 10197; Mouse: 19192

Research Use Only