PAR4 Monoclonal Antibody - BT-MCA2683

PAR4 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2683-50, BT-MCA2683-100

Citations, Manuals and MSDS Available upon request.

Background: Prostate apoptosis response 4 (Par4) is a 38kD protein originally identified as the product of a gene that is upregulated in prostate tumor cells undergoing apoptosis. It is a leucine zipper and death domain containing protein whose levels increase in neurons undergoing apoptosis as a result of trophic factor withdrawal or exposure to oxidative and metabolic insults. Par4 levels are reported to be increased in their lumbar spinal cord specimens further suggesting a role in neuronal degeneration. The tumor suppressor WT1 represses and activates transcription. The loss and/or imbalance of the dual transcriptional activity of WT1 may contribute to Wilms tumor. Par4 is a WT1 interacting protein that also functions as a transcriptional repressor.

Research Areas: Others

Target Protein: PAR4

Applications: WB, IHC

Reactivity: Human

Clonality: Monoclonal

Clone ID: 3G9H7

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: PAR4

Immunogen: Purified recombinant fragment of PAR4(aa1-330) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

UniProt Accession: Q96IZ0

Synonyms: PAWR

GeneID: 5074

Research Use Only