Product Description

PCDAA Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES14231-50, ES14231-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB

Alternate Names: Protocadherin alpha-10 (PCDH-alpha-10)

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human PCDAA AA range: 302-352

Isotype: IgG

Target: PCDAA

Specificity: This antibody detects endogenous levels of PCDAA at Human

Dilution: WB 1:500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.199% sodium azide.

Expression: Brain, Placenta,

Observed Band (KD): 105kD

Function: Alternative Products: Additional isoforms seem to exist,Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain
Similarity: Contains 6 cadherin domains

Subcellular Location: Cell membrane, Single-pass type I membrane protein, [Isoform 2]: Secreted

Storage and Stability: -20°C/1 year

Gene Name: PCDHA10 CNRS8

Protein Name: PCDAA

Research Use Only