Product Description

PCK1 Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-40269-60, E-AB-40269-120, E-AB-40269-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: PCK1

Target Synonym: cytosolic [GTP]; GTP; PCK1; PCKGC; PEP carboxykinase; PEPCK-C; PEPCK1; PEPCKC; Phosphoenolpyruvate carboxykinase 1 (soluble); Phosphoenolpyruvate carboxykinase 1; Phosphoenolpyruvate carboxykinase; Phosphoenolpyruvate carboxykinase; cytosolic [GTP]; Phosphoenolpyruvate carboxykinase; cytosolic; Phosphoenolpyruvate carboxylase; Phosphopyruvate carboxylase

Research Areas: Cancer, Cardiovascular, Metabolism, Signal Transduction

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human, Rat

Application: IHC

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: P07379

Background: This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized.

Concentration: 1 mg/mL

Immunogen: Recombinant Rat Phosphoenolpyruvate carboxykinase, cytosolic [GTP] protein

Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.

Purification Method: Antigen Affinity Purification

Dilution: IHC 1:100-1:200

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only