Product Description

PD-ECGF Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES4144-50, ES4144-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2012],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, IHC, IF, ELISA

Alternate Names: TYMP, ECGF1, Thymidine phosphorylase, TP, Gliostatin, Platelet-derived endothelial cell growth factor, PD-ECGF, TdRPase

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from the N-terminal region of human TYMP. AA range:11-60

Isotype: IgG

Target: PD-ECGF

Specificity: PD-ECGF Polyclonal Antibody detects endogenous levels of PD-ECGF protein.

Dilution: Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Brain, Lung, Placenta, Synovial membrane tissue,

Observed Band (KD): 50kD

Fields: Pyrimidine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism, Bladder cancer

Function: Catalytic Activity: Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate
Disease: Defects in TYMP are the cause of mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) [MIM: 603041], also known as myoneurogastrointestinal encephalomyopathy. MNGIE is an autosomal recessive disease associated with multiple deletions of skeletal muscle mitochondrial DNA (MtDNA). It is clinically characterized by onset between the second and fifth decades of life, ptosis, progressive external ophthalmoplegia, gastrointestinal dysmotility (often pseudoobstruction), diffuse leukoencephalopathy, thin body habitus, peripheral neuropathy, and myopathy
Function: Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
Function: May have a role in maintaining the in

Subcellular Location: cytosol,

Storage and Stability: -20°C/1 year

Gene Name: TYMP

Protein Name: Thymidine phosphorylase

Mouse Gene ID: 72962

Mouse SwissProt Number: Q99N42

Rat Gene ID: 315219

Rat SwissProt Number: Q5FVR2

Research Use Only