Product Description

PDE11 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES14188-50, ES14188-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA, IHC

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human PDE11 AA range: 421-471

Isotype: IgG

Target: PDE11

Specificity: This antibody detects endogenous levels of PDE11 at Human/Mouse/Rat

Dilution: WB 1:500-2000, IHC-p 1:50-300, ELISA 2000-20000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Isoform 1 is present in prostate, pituitary, heart and liver, It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil (Cialis) is not relevant (at protein level), Isoform 2 may be expressed in testis, Isoform 4 is expressed in adrenal cortex,

Molecular Weight (Da): 103kD

Fields: Purine metabolism, Metabolic pathways, Cushing syndrome, Morphine addiction

Function: Catalytic Activity: Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate
Catalytic Activity: Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate
Cofactor: Divalent cations
Disease: Defects in PDE11A are the cause of primary pigmented nodular adrenocortical disease type 2 (PPNAD2) [MIM: 610475]. Primary pigmented nodular adrenocortical disease is a rare bilateral adrenal defect causing ACTH-independent Cushing syndrome. PPNAD2 is characterized by adrenal glands with overall normal size and weight, and multiple small yellow-to-dark brown nodules surrounded by a cortex with a uniform appearance. Microscopically, there are moderate diffuse cortical hyperplasia with mostly nonpigmented nodules, multiple capsular deficits and massive circumscribed and infiltrating extra-adrenal cortical excrescences with micronodules. PPNAD2 leads to Cushing syndrome
Domain: The tandem

Subcellular Location: Cytoplasm, cytosol

Storage and Stability: -20°C/1 year

Gene Name: PDE11A

Protein Name: PDE11

Mouse Gene ID: 241489

Mouse SwissProt Number: P0C1Q2

Rat Gene ID: 140928

Rat SwissProt Number: Q8VID6

Research Use Only