PDE11A Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: A16121-20, A16121-100
Citations, Manuals and SDS Available upon request.
Background: The 3', 5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3', 5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms: PPNAD2; PDE11A
GeneID: 50940
Swiss Prot: Q9HCR9
Tested Applications: ELISA, WB, IF/ICC
Reactivity: Mouse, Rat
Calculated Molecular Weight: 105kDa
Observed Molecular Weight: 105kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 712-933 of human PDE11A (NP_058649.3).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:2000 | IF/ICC: 1:50 - 1:200
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: Mouse brain, Mouse testis, Mouse liver, Rat brain, Rat testis, Rat liver
Cellular Location: Cytoplasm, Cytosol
Keywords: 50940, PDE11A, PPNAD2, phosphodiesterase 11A, dual 3', 5'-cyclic-AMP and -GMP phosphodiesterase 11A, cAMP and cGMP cyclic nucleotide phosphodiesterase 11A, Q9HCR9, Phosphodiesterase 11A, CAMP And CGMP Cyclic Nucleotide Phosphodiesterase 11A, Dual 3, 5-Cyclic-AMP And -GMP Phosphodiesterase 11A, CAMP And CGMP Phosphodiesterase 11A, EC 3.1.4.35, EC 3.1.4.53
Symbol: PDE11A
Category: Polyclonal Antibodies
Research Use Only