PDHA1 Monoclonal Antibody - BT-MCA3345

PDHA1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3345-50, BT-MCA3345-100

Citations, Manuals and MSDS Available upon request.

Background: The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Research Areas: Signal Transduction, Metabolism

Target Protein: PDHA1

Applications: WB, FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 2A2H7

Host: Mouse

Isotype: Mouse IgG2b

Full Product Name: PDHA1

Immunogen: Purified recombinant fragment of human PDHA1 (AA: 241-390) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 43.3kDa

UniProt Accession: P08559

Synonyms: PDHA, PDHAD, PHE1A, PDHCE1A

GeneID: 5160

Research Use Only