PDK1 Monoclonal Antibody - BT-MCA1013

PDK1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA1013-50, BT-MCA1013-100

Citations, Manuals and MSDS Available upon request.

Background: Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene.

Research Areas: Signal transduction; Cancer; Metabolism

Target Protein: PDK1

Applications: WB, IHC-p, IF, ICC, FCM, ELISA

Reactivity: Human,Rat,Monkey

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q15118; Mouse: Q8BFP9; Rat: Q63065

Synonyms: PDK1; PDHK1; Pyruvate dehydrogenase (lipoamide) kinase isozyme 1; mitochondrial; Pyruvate dehydrogenase kinase isoform 1

GeneID: Human: 5163

Research Use Only