Product Description

PEG3 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES6567-50, ES6567-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2009],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, IHC

Alternate Names: PEG3, KIAA0287, ZSCAN24, Paternally-expressed gene 3 protein, Zinc finger and SCAN domain-containing protein 24

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human PEG3. AA range:1031-1080

Isotype: IgG

Target: PEG3

Specificity: PEG3 Polyclonal Antibody detects endogenous levels of PEG3 protein.

Dilution: WB 1:500-2000, IHC-p 1:50-300

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Brain, glial cells, astrocytes, embryo, placenta, testis, ovary and uterus, In the placenta it is found in the layer of villous cytotrophoblast cells while in the ovary it is found in the cells of the ovarian stroma including the thecal layers around the follicles, Expression is highly repressed in glioma cell lines,

Observed Band (KD): 181kD

Function: Function: Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between TP53/p53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells
Function: May be involved in transcriptional regulation
Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
Similarity: Contains 1 KRAB domain
Similarity: Contains 1 SCAN box domain
Similarity: Contains 12 C2H2-type zinc fingers
Similarity: Contains 5 C2H2-type zinc fingers
Subunit: Homodimer. Interacts with SIAH1A and SIAH2. Interacts with TRAF2
Tissue Specificity: Brain, glial cells, astrocytes, embryo, placenta, testis, ovary and utreus. In the placenta it is found in the layer of villous cytotrophoblast cells while in the ovary it is fou

Subcellular Location: Nucleus Cytoplasm

Storage and Stability: -20°C/1 year

Gene Name: PEG3

Protein Name: Paternally-expressed gene 3 protein

Mouse SwissProt Number: Q3URU2

Research Use Only