Product Description

PEPC Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES20649-50, ES20649-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009],

Reactivity: Plants

Host: Rabbit

Applications: WB

Alternate Names: PGC, Gastricsin, Pepsinogen C

Clonality: Polyclonal

Immunogen: Synthetic Peptide of PEPC

Isotype: IgG

Target: PEPC

Specificity: The antibody detects endogenous PEPC protein.

Dilution: WB: 1:2000-5000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formlation: PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

Expression: Brain, Liver, Placenta, Stomach,

Observed Band (KD): 105-109kD

Function: Catalytic Activity: More restricted specificity than pepsin A, but shows preferential cleavage at Tyr-|-Xaa bonds. High activity on hemoglobin
Function: Hydrolyzes a variety of proteins
Similarity: Belongs to the peptidase A1 family

Subcellular Location: extracellular space, extracellular exosome,

Storage and Stability: -20°C/1 year

Gene Name: PGC

Protein Name: Gastricsin

Research Use Only