Product Description

PERK (Phospho-Thr982) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS66100-50, BS66100-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticμlum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.

Category: Primary Antibody

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, IHC

Alternate Names: p-PERK(Thr980), PERK(Phospho Thr980), PERK(Phospho T980), HRI, HsPEK, Pancreatic eIF2-alpha kinase, PEK, PRKR like endoplasmic reticμlum kinase, WRS, DKFZp781H1925, EC 2.7.11.1, EIF2AK3, Eukaryotic translation initiation factor 2 alpha kinase 3, Heme regμlated EIF2 alpha kinase

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylated

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human PERK.

Dilution: WB 1:500 - 1:1000
IHC 1:100 - 1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: PERK (Phospho-Thr980) polyclonal antibody detects endogenous levels of PERK protein only when phosphorylated at Thr980.

Molecular Weight: ~ 140 kDa

Pathway: Translational Contral Regμlation of elF2,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9NZJ5

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only