PGA5 Monoclonal Antibody - BT-MCA4580

PGA5 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4580-50, BT-MCA4580-100

Citations, Manuals and MSDS Available upon request.

Background: PGA5: Pepsinogen 5, group I (pepsinogen A). Pepsinogens are the inactive precursors of pepsin, the major acid protease found in the stomach. Pepsin is one of the main proteolytic enzymes secreted by the gastric mucosa. Pepsin consists of a single polypeptide chain and arises from its precursor, pepsinogen, by removal of a 41 amino acid segment from the N-terminus. Pepsinogen is synthesized in the stomach lining, and hydrochloric acid, also produced by the gastric mucosa, is necessary to convert the inactive enzyme and to maintain the optimum acidity (pH 1-3) for pepsin function. Pepsin is particularly effective in cleaving peptide bonds involving aromatic amino acids. Pepsin shows extremely broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. PGA5 is a member of the subfamily A1 within the pepsin family and is the predominant endopeptidase in the gastric juice of vertebrates. PGA5 is inhibited by ovUS-1, a uterine serpin.

Research Areas: Others

Target Protein: PGA5

Applications: WB, IHC

Reactivity: Human

Clonality: Monoclonal

Clone ID: 2C1

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: PGA5

Immunogen: Purified recombinant fragment of human PGA5 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 42kDa

UniProt Accession: P0DJD9

Synonyms: Pepsinogen 5, Pepsin A

GeneID: 5222

Research Use Only