Product Description

PGD Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES6578-50, ES6578-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: 6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IF, ELISA

Alternate Names: PGD, PGDH, 6-phosphogluconate dehydrogenase, decarboxylating

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human PGD. AA range:71-120

Isotype: IgG

Target: PGD

Specificity: PGD Polyclonal Antibody detects endogenous levels of PGD protein.

Dilution: IHC-p: 100-300.Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Heart, Lung,

Observed Band (KD): 40kD

Fields: Pentose phosphate pathway, Glutathione metabolism, Metabolic pathways, Carbon metabolism

Function: Catalytic Activity: 6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH
Pathway: Carbohydrate degradation, pentose phosphate pathway, D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3
Similarity: Belongs to the 6-phosphogluconate dehydrogenase family
Subunit: Homodimer

Subcellular Location: Cytoplasm

Storage and Stability: -20°C/1 year

Gene Name: PGD

Protein Name: 6-phosphogluconate dehydrogenase decarboxylating

Mouse Gene ID: 110208

Mouse SwissProt Number: Q9DCD0

Rat Gene ID: 1.0036e+008

Rat SwissProt Number: P85968

Research Use Only