Phospho-20S ProteasomeAlpha3 (S250) Polyclonal Antibody - BT-PHS00396

Phospho-20S ProteasomeAlpha3 (S250) Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-PHS00396-20, BT-PHS00396-50, BT-PHS00396-100

Citations, Manuals and MSDS Available upon request.

Background: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMA3 (proteasome subunit alpha 3) encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified.

Research Areas: Cell Biology

Target Protein: PSMA3

Applications: WB, IHC-p, ELISA

Reactivity: Human, mouse, rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Phospho-20S Proteasome alpha3 (S250) Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 28433

UniProt Accession: Human: P25788; Mouse: O70435; Rat: P18422

Synonyms: PSMA3; HC8; PSC8; Proteasome subunit alpha type-3; Macropain subunit C8; Multicatalytic endopeptidase complex subunit C8; Proteasome component C8

GeneID: Human: 5684; Mouse: 19167; Rat: 29670

Research Use Only