Phospho-ACK (Y284) Polyclonal Antibody - BT-PHS00897

Phospho-ACK (Y284) Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-PHS00897-20, BT-PHS00897-50, BT-PHS00897-100

Citations, Manuals and MSDS Available upon request.

Background: TNK2 encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The tyrosine kinase non receptor 2 may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.

Research Areas: Signal Transduction; Cancer

Target Protein: TNK2

Applications: WB, IHC-p, IF, ELISA

Reactivity: Human, mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Phospho-ACK (Y284) Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 114327

UniProt Accession: Human: Q07912; Mouse: O54967

Synonyms: TNK2; ACK1; Activated CDC42 kinase 1; ACK-1; Tyrosine kinase non-receptor protein 2

GeneID: Human: 10188; Mouse: 51789

Research Use Only