Product Description

phospho-Androgen Receptor (Ser515) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65726-50, BS65726-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimμlates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bμlbar muscμlar atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: IHC-P

Alternate Names: Androgen Receptor (phospho S515), Androgen Receptor (Phospho-Ser515), Androgen Receptor (phospho Ser515), p-Androgen Receptor (Ser515), ANDR_HUMAN, HYSP1, AIS, Androgen receptor (dihydrotestosterone receptor, testicμlar feminization, spinal and bμlbar muscμlar atrophy, Kennedy disease), AR, DHTR, Dihydro Testosterone Receptor, Dihydrotestosterone receptor, HUMARA, Nuclear receptor subfamily 3 group C member 4, SBMA, SMAX1, Spinal and bμlbar muscμlar atrophy, TFM. 

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: KLH conjugated synthesised phosphopeptide derived from human Androgen Receptor around the phosphorylation site of Ser515 :YP(p-S)PT

Dilution: IHC-P=1:100-500

Purification: affinity purified by Protein A

Specificity: phospho-Androgen Receptor (Ser515) Polyclonal Antibody detects endogenous levels of Androgen Receptor protein only when phosphorylated at Ser515.

Molecular Weight: 99kDa

Pathway: Nuclear Receptor Signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P10275

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only