Phospho-ATP-citrate synthase (S455) Polyclonal Antibody - BT-PHS00686

Phospho-ATP-citrate synthase (S455) Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-PHS00686-20, BT-PHS00686-50, BT-PHS00686-100

Citations, Manuals and MSDS Available upon request.

Background: ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

Research Areas: Signal Transduction; Metabolism

Target Protein: ACLY

Applications: WB, IHC-p, ELISA

Reactivity: Human, mouse, rat, monkey

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Phospho-ATP-citrate synthase (S455) Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 120839

UniProt Accession: Human: P53396; Mouse: Q91V92; Rat: P16638

Synonyms: ACLY; ATP-citrate synthase; ATP-citrate; pro-S-)-lyase; ACL; Citrate cleavage enzyme

GeneID: Human: 47; Mouse: 104112; Rat: 24159

Research Use Only