Phospho-BLNK (Y96) Polyclonal Antibody - BT-PHS00687

Phospho-BLNK (Y96) Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-PHS00687-20, BT-PHS00687-50, BT-PHS00687-100

Citations, Manuals and MSDS Available upon request.

Background: BLNK encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. B-cell linker bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene.

Research Areas: Immunology; Signal Transduction

Target Protein: BLNK

Applications: WB, IHC-p, ELISA

Reactivity: Human, mouse, monkey

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Phospho-BLNK (Y96) Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 50466

UniProt Accession: Human: Q8WV28; Mouse: Q9QUN3

Synonyms: BLNK; BASH; SLP65; B-cell linker protein; B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; Cytoplasmic adapter protein; Src homology 2 domain-

GeneID: Human: 29760; Mouse: 17060

Research Use Only