Phospho-Casein Kinase IAlpha (Y321) Polyclonal Antibody - BT-PHS00392

Phospho-Casein Kinase IAlpha (Y321) Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-PHS00392-20, BT-PHS00392-50, BT-PHS00392-100

Citations, Manuals and MSDS Available upon request.

Background: CSNK1A1 (Casein Kinase 1 Alpha 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Infectious disease. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK1G2. asein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at Ser-45. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis (PubMed: 11955436, PubMed: 1409656, PubMed: 18305108). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed: 23902688). asein kinase I (CK1) is a monomeric serine-threonine protein kinase with 7 isoforms: alpha, beta, gamma1, gamma2, gamma3, delta and epsilon. CK1 is involved in many cellular processes including DNA repair, cell division, nuclear localization and membrane transport. Isoforms are also integral to development.

Research Areas: Signal Transduction

Target Protein: CSNK1A1

Applications: WB, IHC-p, ELISA

Reactivity: Human, mouse, rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Phospho-Casein Kinase Ialpha (Y321) Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 38915

UniProt Accession: Human: P48729; Mouse: Q8BK63; Rat: P97633

Synonyms: CSNK1A1; Casein kinase I isoform alpha; CKI-alpha; CK1

GeneID: Human: 1452; Rat: 113927

Research Use Only