Phospho-Catenin-Beta (S37) Polyclonal Antibody - BT-PHS00047

Phospho-Catenin-Beta (S37) Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-PHS00047-20, BT-PHS00047-50, BT-PHS00047-100

Citations, Manuals and MSDS Available upon request.

Background: Catenin beta 1 encoded by CTNNB1 is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. Catenin beta 1 also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, catenin beta 1 binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in CTNNB1 are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for CTNNB1.

Research Areas: Signal Transduction

Target Protein: CTNNB1

Applications: WB, IHC-p, IF, ELISA

Reactivity: Human, mouse, rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Phospho-Catenin-beta (S37) Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 85497

UniProt Accession: Human: P35222; Mouse: Q02248; Rat: Q9WU82

Synonyms: CTNNB1; CTNNB; OK/SW-cl.35; Catenin beta-1; Beta-catenin

GeneID: Human: 1499; Mouse: 12387; Rat: 84353

Research Use Only