Phospho-Caveolin-1 (Y14) Polyclonal Antibody - BT-PHS00050

Phospho-Caveolin-1 (Y14) Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-PHS00050-20, BT-PHS00050-50, BT-PHS00050-100

Citations, Manuals and MSDS Available upon request.

Background: The scaffolding protein (caveolin 1) encoded by CAV1 is the main component of the caveolae plasma membranes found in most cell types. Caveolin 1 links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. CAV1 is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in CAV1 have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.

Research Areas: Cardiovascular

Target Protein: CAV1

Applications: WB, ELISA

Reactivity: Human, mouse, rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Phospho-Caveolin-1 (Y14) Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 20472

UniProt Accession: Human: Q03135; Mouse: P49817; Rat: P41350

Synonyms: CAV1; CAV; Caveolin-1

GeneID: Human: 857; Mouse: 12389

Research Use Only