Product Description

Phospho-Doublecortin (Ser297) Recombinant Rabbit mAb

Sizes: 50μl, 100μl

Catalogue Numbers: BS43269-50, BS43269-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubμles. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regμlating the organization and stability of microtubμles. In addition, the encoded protein interacts with LIS1, the regμlatory gamma subunit of platelet activating factor acetylhydrolase. Studies in knockout mice lacking this gene and the LIS1 gene suggest that the molecμlar interaction of these two genes is important in both in neuronal migration and neurogenesis, and there is a cortical role of this gene in nuclear translocation and positioning of the mitotic spindle in radial glial mitotic division. Mμltiple transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

Category: Primary Antibody

Reactivity: Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IP

Alternate Names: Dbct

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Phosphorylated

Immunogen: A synthetic phosphopeptide corresponding to residues surrounding
Ser297 of mouse Doublecortin

Dilution: WB: 1:1000 IHC: 1:20-1:500 IP: 1:20

Purification: Affinity Purification

Specificity: IgG

Molecular Weight: 41 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O88809

Product: Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Research Use Only