Product Description

Phospho-FGFR3-Y724 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS74224-50, BS74224-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A fμll-length representative protein woμld consist of an extracellμlar region, composed of three immunoglobμlin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellμlar portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals,μltimately influencing mitogenesis and differentiation. This particμlar family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and mμltiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.

Category: Primary Antibody

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Alternate Names: ACH, CD333, CEK2, HSFGFR3EX, JTK4, FGFR3

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylated

Immunogen: A synthetic phosphorylated peptide around Y724 of human FGFR3(NP_000133.1).

Dilution: WB, 1:500 - 1:2000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Phosphorylated

Molecular Weight: 125KDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P22607

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only