Product Description

Phospho-FLT3-Y589/591 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS74148-50, BS74148-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a class III receptor tyrosine kinase that regμlates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellμlar domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates mμltiple cytoplasmic effector molecμles in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that resμlt in the constitutive activation of this receptor resμlt in acute myeloid leukemia and acute lymphoblastic leukemia.

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB

Alternate Names: FLT3, CD135, FLK-2, FLK2, STK1

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylated

Immunogen: A synthetic phosphorylated peptide around Y589 & Y591 of human FLT3(NP_004110.2).

Dilution: WB, 1:500 - 1:2000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Phosphorylated

Molecular Weight: 160KDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P36888

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only