Phospho-IRE1 (Ser724) Monoclonal Antibody-MB11870

Phospho-IRE1 (Ser724) Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB11870-50, MB11870-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: O75460

Host: Rabbit

Reactivity: Human

Applications: WB,IP

All Applications: WB: 1/500-1/1000 IP: 1/20

Background: Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Phospho-IRE1 in MCF-7, HL-60Lysates using Phospho-IRE1 antibody.

Bioworld Molecular Weight: Calculated MW: 110 kDa; Observed MW: 110 kDa

Specificity: IgG

Alternative Name: ERN1; IRE1; Serine/threonine-protein kinase/endoribonuclease IRE1; Endoplasmic reticulum-to-nucleus signaling 1; Inositol-requiring protein 1; hIRE1p; Ire1-alpha; IRE1a

Immunogen: A synthetic phosphopeptide corresponding to residues surrounding Ser724 of human IRE1

Conjugate: Unconjugated

Modification: Phosphorylated