Product Description

phospho-MCK10 (Tyr513) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65946-50, BS65946-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecμles are involved in the regμlation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellμlar domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particμlarly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene resμlts in mμltiple transcript variants.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Pig, Cow, Horse

Host: Rabbit

Applications: WB

Alternate Names: MCK10 (phospho Y513), p-MCK10 (phospho Y513), CAK, CD167a, DDR1CD 167, CD167, Cell adhesion kinase, DDR 1, DDR, DDR1, Discoidin domain receptor, Discoidin receptor tyrosine kinase isoform a, EDDR 1, Epithelial discoidin domain receptor 1, Epithelial specific receptor kinase, Mammarian carcinoma kinase 10, Neuroepithelial tyrosine kinase, Neurotrophic tyrosine kinase receptor type 4, NTRK 4, PTK 3, PTK 3A protein tyrosine kinase 3A, Receptor tyrosine kinase NEP, RTK 6, TRK E, Tyrosine kinase receptor E, DDR1_HUMAN.

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: KLH conjugated synthesised phosphopeptide derived from human MCK10 around the phosphorylation site of Tyr513:PA(p-Y)RL

Dilution: IHC-P=1:100-500

Purification: affinity purified by Protein A

Specificity: phospho-MCK10 (Tyr513) Polyclonal Antibody detects endogenous levels of MCK10 protein only when phosphorylated at Tyr513.

Molecular Weight: 120 kD

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q08345

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only