Product Description

Phospho-MET-Y1234/1235 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS79394-50, BS79394-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disμlfide bonds to form the mature receptor. Further processing of the beta subunit resμlts in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellμlar survival, embryogenesis, and cellμlar migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellμlar carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with mμltiple human cancers.

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB

Alternate Names: MET, AUTS9, DFNB97, HGFR, RCCP2, c-Met

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylated

Immunogen: A synthetic phosphorylated peptide around Y1234 & Y1235 of human MET(NP_000236.2).

Dilution: WB, 1:500 - 1:2000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Phosphorylated

Molecular Weight: 145KDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P08581

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only