Product Description

Phospho-MLKL (Ser345) Recombinant Rabbit mAb

Sizes: 50μl, 100μl

Catalogue Numbers: BS43185-50, BS43185-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain, however, is thought to lack protein kinase activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (Rip3), which is a key signaling molecμle in necroptosis pathway. Knockout of this gene in mice showed that it is essential for necroptosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]

Category: Primary Antibody

Reactivity: Mouse

Host: Rabbit

Applications: WB, IP

Alternate Names: 9130019I15Rik

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Phosphorylated

Immunogen: A synthetic phosphopeptide corresponding to residues surrounding Ser345 of mouse MLKL

Dilution: WB: 1:1000 IP: 1:100

Purification: Affinity Purification

Specificity: IgG

Molecular Weight: 54 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9D2Y4

Product: Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Research Use Only