Product Description

phospho-TNIK (Ser769) Polyclonal Antibody

Size: 100μl

Catalogue Number: BS65918-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: TNIK is a MSN protein kinase that interacts with both TNF receptor-associated factor 2 (TRAF2) and the adapter protein NCK. The protein has been shown to activate the c-Jun N-terminal kinase pathway when over expressed in Phoenix-A cells. TNIK has been shown to phosphorylate gelsolin, the principal intracellμlar and extracellμlar actin-severing protein, in vitro. This and evidence from mutational studies suggest that TNIK functions in the regμlation of the cytoskeleton. Northern analysis indicates TNIK expression in human heart, skeletal muscle, and brain, with lower levels of expression in kidney, liver, lung, and pancreas. ESTs have been isolated from human tissue libraries, including normal amnion, gallbladder and skin.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Dog, Pig, Cow, Horse

Host: Rabbit

Applications: IHC-P

Alternate Names: TNIK (phospho S769), p-TNIK (phospho S769), TNIK (phospho-Ser769), TNIK (phospho-S769), p-TNIK (Ser769), p-TNIK (S769), Traf2 and NCK interacting kinase, 1500031A17RIK, 4831440I19RIK, AI451411, C530008O15Rik, C630040K21RIK, KIAA0551, MGC189819, MGC189859, RGD1561817, TNIK, TNIK_HUMAN, TRAF2 and NCK-interacting protein kinase.

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: KLH conjugated Synthesised phosphopeptide derived from human TNIK around the phosphorylation site of Ser769:EG(p-S)PV

Dilution: IHC-P=1:100-500

Purification: affinity purified by Protein A

Specificity: phospho-TNIK (Ser769) Polyclonal Antibody detects endogenous levels of TNIK protein only when phosphorylated at Ser769.

Molecular Weight: 150kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9UKE5

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only