PHX2B Polyclonal Antibody - BT-AP13004

PHX2B Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP13004-20, BT-AP13004-50, BT-AP13004-100

Citations, Manuals and MSDS Available upon request.

Background: The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome.

Research Areas: Epigenetics and nuclear signaling; Neuroscience

Target Protein: PHOX2B

Applications: WB, ELISA

Reactivity: Human, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Paired mesoderm homeobox protein 2B

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q99453; Mouse: O35690

Synonyms: Paired mesoderm homeobox protein 2B;Neuroblastoma Phox;NBPhox;PHOX2B homeodomain protein;Paired-like homeobox 2B

GeneID: Human: 8929

Research Use Only