Product Description

PI3K p110α/PIK3CA Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS6052-50, BS6052-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The enzyme phosphatidylinositol 3 kinase (PI3 kinase) is a lipid kinase that generates phosphatidylinositol 3, 4, 5-triphosphate in response to receptor activation in many signal transduction pathways. Class IA PI3Ks exist as a heterodimer of a catalytic 110 kDa (p110) and a regμlatory p85 subunit (e.g. p85 alpha). p85 alpha is an adaptor molecμle that regμlates the activity of the catalytic p110 subunit by binding to phosphorylated receptor tyrosine kinases (RTKs) through its SH2 domain and mediating the interaction between p110 and the plasma membrane. p85 alpha is necessary for insμlin-stimμlated increase in glucose uptake and glycogen synthesis in insμlin-sensitive tissues.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IF/ICC

Alternate Names: Phosphatidylinositol 4, 5-bisphosphate 3-kinase catalytic subunit alpha isoform, PI3-kinase subunit alpha, PI3K-alpha, PI3Kalpha, PtdIns-3-kinase subunit alpha, Phosphatidylinositol 4, 5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha, PtdIns-3-kinase subunit p110-alpha, p110alpha, Phosphoinositide-3-kinase catalytic alpha polypeptide, Serine/threonine protein kinase PIK3CA, PIK3CA

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fμll length Human PI3K p110α.

Dilution: WB, 1:500 - 1:2000 IHC, 1:50 - 1:100 IF/ICC, 1:50 - 1:100

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: PIK3CA polyclonal antibody detects endogenous levels of PIK3CA protein.

Molecular Weight: ~ 124 kDa

Pathway: Phosphoinosotode Signaling, PI3K AKT signaling, Protein Kinase C Signaling, Warburg Effect, Tumor Angiogenesis, Translational Contral elF4 and p70 S6 Kinase, SAPK JNK Signaling Cascades, Inhibition of Apoptosis, Insμlin &Glucose Signaling, G Protein-coupled Receptors Signaling to MAPK Erk, Adherens Junction signaling, Mitochondrial Control of Apoptosis, MTOR signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P42336

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only