Product Description

PI51A Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES14115-50, ES14115-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Alternate Names: Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1-alpha) (PtdIns(4)P-5-kinase 1 alpha) (EC 2.7.1.68) (68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha) (Phosphatidylinositol 4-phosphate 5-kinase type I alpha) (PIP5KIalpha)

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human PI51A AA range: 270-320

Isotype: IgG

Target: PI51A

Specificity: This antibody detects endogenous levels of PI51A at Human/Mouse

Dilution: WB 1:500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.99% sodium azide.

Expression: Highly expressed in heart, placenta, skeletal muscle, kidney and pancreas, Detected at lower levels in brain, lung and liver,

Observed Band (KD): 60kD

Fields: Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, Phospholipase D signaling pathway, Endocytosis, Focal adhesion, Fc gamma R-mediated phagocytosis, Regulation of actin cytoskeleton, Yersinia infection, Choline metabolism in cancer

Function: Catalytic Activity: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
Function: Participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2
Similarity: Contains 1 PI5K domain
Subcellular Location: Associated with the plasma membrane and with internal membranes. Associated with Golgi stacks (By similarity). Detected on RAC1-induced plasma membrane ruffles, and on membrane ruffles induced by platelet-derived growth factor
Subunit: Interacts with ARF1, RAC1, PLD1, PLD2 and JUB
Tissue Specificity: Highly expressed in heart, placenta, skeletal muscle, kidney and pancreas. Detected at lower levels in brain, lung and liver

Subcellular Location: Cell membrane Cytoplasm Nucleus Nucleus speckle Cell projection, ruffle Cell projection, lamellipodium Colocalizes with RAC1 at actin-rich membrane ruffles (PubMed:20660631) Localizes to nuclear speckles and associates with TUT1 to regulate polyadenylation of selected mRNAs (PubMed:18288197)

Storage and Stability: -20°C/1 year

Gene Name: PIP5K1A

Protein Name: PI51A

Mouse Gene ID: 18720

Mouse SwissProt Number: P70182

Research Use Only