PIG11 (P93) Polyclonal Antibody-BS1865

PIG11 (P93) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS1865-50, BS1865-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: O14683

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: IHC

All Applications: IHC: 1:50~1:200

Background: PIG11 (p53-induced gene 11 protein), also known as TP53I11, is a 177 amino acid tumor suppressor belonging to the p53-induced protein gene (PIG) family. The PIG gene family encodes redox-controlling proteins that are involved in p53 tumor suppressor activity. It is suggested that PIG11 is involved in arsenic trioxide As(2)O(3)-induced apoptosis in certain cell lines and may play a significant role in tumor suppression through promotion of cell apoptosis. The gene encoding PIG11 maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry (IHC) analyzes of PIG11 (P93) pAb in paraffin-embedded human colorectal carcinoma tissue at 1:50.

Bioworld Molecular Weight: ~ 21 kDa

Specificity: PIG11 (P93) polyclonal antibody detects endogenous levels of PIG11 protein.

Alternative Name: Tumor protein p53-inducible protein 11; p53-induced gene 11 protein; TP53I11; PIG11

Immunogen: Synthetic peptide, corresponding to amino acids 71-120 of Human PIG11.

Conjugate: Unconjugated

Modification: Unmodified