Product Description

PIWL2 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES14101-50, ES14101-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: PIWIL2 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003 [PubMed 12906857]).[supplied by OMIM, Mar 2008],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Alternate Names: Piwi-like protein 2 (Cancer/testis antigen 80) (CT80)

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human PIWL2 AA range: 754-804

Isotype: IgG

Target: PIWL2

Specificity: This antibody detects endogenous levels of PIWL2 at Human/Mouse

Dilution: WB 1:500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.292% sodium azide.

Expression: Expressed in adult testis and in most tumors,

Observed Band (KD): 105kD

Function: Catalytic Activity: 3-beta-hydroxy-Delta(5)-steroid + NAD(+) = 3-oxo-Delta(5)-steroid + NADH
Catalytic Activity: Cholest-5-ene-3-beta,7-alpha-diol + NAD(+) = 7-alpha-hydroxycholest-4-en-3-one + NADH
Disease: Defects in HSD3B7 are the cause of congenital bile acid synthesis defect type 1 (CBAS1) [MIM: 607765], also known as neonatal progressive intrahepatic cholestasis. CBAS1 is due to a primary defect in bile synthesis leading to progressive liver disease. Clinical features include neonatal jaundice, severe intrahepatic cholestasis and cirrhosis
Function: Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells. Its presence in oocytes suggests tha

Subcellular Location: Cytoplasm Present in chromatoid body Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis

Storage and Stability: -20°C/1 year

Gene Name: PIWIL2 HILI

Protein Name: PIWL2

Mouse Gene ID: 57746

Mouse SwissProt Number: Q8CDG1

Research Use Only