Product Description

PKC δ/RKCD (phospho-S664) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS64162-50, BS64162-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Protein kinase C (PKC) family members influence a variety of cellμlar functions, including cell growth, cell differentiation, hormone secretion and membrane function. PKC isoforms are calcium and phospholipid-dependent serine/threonine protein kinases. Diacylglycerols (DAG) and tumor promoting phorbol esters bind to and activate PKC. PKC δ phosphorylation on Thr 507 mediates inhibition of JAK2 and Stat3 function. PKC δ phosphorylates and associates with Stat3 on Ser 727 following induction by IL-6 to negatively regμlate the DNA binding and transcriptional activity of Stat3. The Tyr 525, 523 and 565 residues in the catalytic domain are crucial for activation of PKC δ. The Tyr 52, 155 and 187 residues of PKC δ reside within a regμlatory domain. The residue Ser 643 appears to be an autophosphorylation site.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Protein kinase C delta type, Tyrosine-protein kinase PRKCD, nPKC-delta, Sphingosine-dependent protein kinase-1, SDK1, PRKCD

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: Synthetic phosphopeptide derived from human PKCD around the phosphorylation site of Serine 664

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: p-RKCD (S664) Polyclonal Antibody detects endogenous levels of p-RKCD (S664) protein only when phosphorylated at Ser664.

Molecular Weight: ~ 78 kDa

Pathway: Protein Kinase C Signaling, Inhibition of Apoptosis, Mitochondrial Control of Apoptosis,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q05655

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only