PKCAlpha/beta II (Phospho-Thr638/641) Rabbit Polyclonal Antibody - BT-AP11959

PKCAlpha/beta II (Phospho-Thr638/641) Rabbit Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP11959-20, BT-AP11959-50, BT-AP11959-100

Citations, Manuals and MSDS Available upon request.

Background: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters| a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes| such as cell adhesion| cell transformation| cell cycle checkpoint| and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.

Research Areas: Signal transduction; Cardiovascular; Cancer

Applications: WB

Reactivity: Human, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: PKC alpha/beta II

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P17252; Mouse: P20444; Rat: P05696

Synonyms: PKCα/β II;Thr638/641; Protein kinase C alpha type; PKC-A; PKC-alpha; EC 2.7.11.13

GeneID: Human: 5578; Mouse: 18750

Research Use Only