PKD1 (G459) Polyclonal Antibody-BS1581

PKD1 (G459) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS1581-50, BS1581-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q15139

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: IHC

All Applications: IHC: 1:50~1:200

Background: Activation of PKC is one of the earliest events in a cascade leading to a variety of cellular responses such as secretion, gene expression, proliferation and muscle contraction. Protein kinase D (PKD), also called PKCμ, is a serine/threonine kinase whose activation is dependent on the phosphorylation of two activation loop sites, Ser744 and Ser748, via a PKC-dependent signaling pathway. In addition to the two activation loop sites, the carboxy-terminal Ser916 has been identified as an autophosphorylation site for PKD/PKCμ. Phosphorylation at Ser916 correlates with PKD/PKCμ catalytic activity.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry (IHC) analyzes of PKD1 (G459) pAb in paraffin-embedded human brain tissue.

Bioworld Molecular Weight: ~ 115 kDa

Specificity: PKD1 (G459) polyclonal antibody detects endogenous levels of PKD1 protein.

Alternative Name: Serine/threonine-protein kinase D1; Protein kinase C mu type; Protein kinase D; nPKC-D1; nPKC-mu; PRKD1; PKD; PKD1; PRKCM; PKCμ; PKC μ; PKC-μ; PKC mu; PKCmu;

Immunogen: Synthetic peptide, corresponding to amino acids 424-482 of Human PKD1.

Conjugate: Unconjugated

Modification: Unmodified