PKN1 Monoclonal Antibody - BT-MCA2014

PKN1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2014-50, BT-MCA2014-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Research Areas: Signal Transduction

Target Protein: PKN1

Applications: IHC, ICC, FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 4H10B1

Host: Mouse

Isotype: Mouse IgG2b

Full Product Name: PKN1

Immunogen: Purified recombinant fragment of human PKN1 (AA: 442-620) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide.

Molecular Weight (Da): 104kDa

UniProt Accession: Q16512

Synonyms: DBK, PKN, PAK1, PRK1, PAK-1, PRKCL1, PKN-ALPHA

GeneID: 5585

Research Use Only